2017

  • Antidiabetic Polypill Improves Central Pathology and Cognitive Impairment in a Mixed Model of Alzheimer’s Disease and Type 2 Diabetes.
    Infante-Garcia C, Ramos-Rodriguez JJ, Hierro-Bujalance C, Ortegon E, Pickett E, Jackson R, Hernandez-Pacho F, Spires-Jones T, Garcia-Alloza M.
    Mol Neurobiol. 2018 Jul;55(7):6130-6144. doi: 10.1007/s12035-017-0825-7. Epub 2017 Dec 9.
    PubMed

  • Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer’s Disease.
    Ramos-Rodriguez JJ, Spires-Jones T, Pooler AM, Lechuga-Sancho AM, Bacskai BJ, Garcia-Alloza M.
    Mol Neurobiol. 2017 Jul;54(5):3428-3438. doi: 10.1007/s12035-016-9921-3. Epub 2016 May 14.
    PubMed

2016

  • Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer’s disease.
    Jackson RJ, Rudinskiy N, Herrmann AG, Croft S, Kim JM, Petrova V, Ramos-Rodriguez JJ, Pitstick R, Wegmann S, Garcia-Alloza M, Carlson GA, Hyman BT, Spires-Jones TL.
    Eur J Neurosci. 2016 Dec;44(12):3056-3066. doi: 10.1111/ejn.13442. Epub 2016 Nov 12.
    PubMed

2013

  • Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice.
    Ramos-Rodriguez JJ, Ortiz O, Jimenez-Palomares M, Kay KR, Berrocoso E, Murillo-Carretero MI, Perdomo G, Spires-Jones T, Cozar-Castellano I, Lechuga-Sancho AM, Garcia-Alloza M.
    Psychoneuroendocrinology. 2013 Nov;38(11):2462-75. doi: 10.1016/j.psyneuen.2013.05.010. Epub 2013 Jun 21.
    PubMed

  • Rapid beta-amyloid deposition and cognitive impairment after cholinergic denervation in APP/PS1 mice.
    Ramos-Rodriguez JJ, Pacheco-Herrero M, Thyssen D, Murillo-Carretero MI, Berrocoso E, Spires-Jones TL, Bacskai BJ, Garcia-Alloza M.
    J Neuropathol Exp Neurol. 2013 Apr;72(4):272-85. doi: 10.1097/NEN.0b013e318288a8dd.
    PubMed

2010

  • Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer’s disease.
    Coma M, Serenó L, Da Rocha-Souto B, Scotton TC, España J, Sánchez MB, Rodríguez M, Agulló J, Guardia-Laguarta C, Garcia-Alloza M, Borrelli LA, Clarimón J, Lleó A, Bacskai BJ, Saura CA, Hyman BT, Gómez-Isla T.
    Neurobiol Dis. 2010 Jun;38(3):482-91. doi: 10.1016/j.nbd.2010.01.019. Epub 2010 Feb 10.
    PubMed

2009

  • Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques.
    Koffie RM, Meyer-Luehmann M, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, Micheva KD, Smith SJ, Kim ML, Lee VM, Hyman BT, Spires-Jones TL.
    Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):4012-7. doi: 10.1073/pnas.0811698106. Epub 2009 Feb 19.
    PubMed

2008

  • Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer’s disease.
    Meyer-Luehmann M, Spires-Jones TL, Prada C, Garcia-Alloza M, de Calignon A, Rozkalne A, Koenigsknecht-Talboo J, Holtzman DM, Bacskai BJ, Hyman BT.
    Nature. 2008 Feb 7;451(7179):720-4. doi: 10.1038/nature06616.
    PubMed